ATC Code A02BC02
Formula C16H15F2N3O4S
Molar Mass (g·mol−1) 383,37
Physical State solid
Melting Point (°C) 139–140
PKS Value 3.92
CAS Number 102625-70-7
PUB Number 4679
Drugbank ID DB00213
Solubility moderate in water / poor in ethanol


Pantoprazole is a drug from the group of proton pump inhibitors. Pantoprazole reduces the overproduction of stomach acid and is therefore used to treat reflux oesophagitis and stomach and duodenal ulcers. It is administered in the form of tablets and is no longer available by prescription.



Pantoprazole is an irreversible inhibitor at proton pumps in the gastric mucosa. It irreversibly binds to these pumps and prevents protons, which are essential for the formation of gastric acid, from entering the stomach.


Panotprazole is absorbed in the intestine and reaches its highest plasma concentration at 2-3 hours after ingestion. Oral bioavailability is approximately 77% and plasma protein binding is approximately 98%. The active substance is degraded by the CYP-450 system in the liver and the majority is subsequently excreted in the urine.


Side effects

Pantoprazole is considered to be a very safe drug with few side effects. Rare side effects include dizziness, headache, and diarrhea.



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