Pantoprazole

Pantoprazole
ATC Code A02BC02
Formula C16H15F2N3O4S
Molar Mass (g·mol−1) 383,37
Physical State solid
Melting Point (°C) 139–140
PKS Value 3.92
CAS Number 102625-70-7
PUB Number 4679
Drugbank ID DB00213
Solubility moderate in water / poor in ethanol

Basics

Pantoprazole is a drug from the group of proton pump inhibitors. Pantoprazole reduces the overproduction of stomach acid and is therefore used to treat reflux oesophagitis and stomach and duodenal ulcers. It is administered in the form of tablets and is no longer available by prescription.

Pharmacology

Pharmacodynamics

Pantoprazole is an irreversible inhibitor at proton pumps in the gastric mucosa. It irreversibly binds to these pumps and prevents protons, which are essential for the formation of gastric acid, from entering the stomach.

Pharmacokinetics

Panotprazole is absorbed in the intestine and reaches its highest plasma concentration at 2-3 hours after ingestion. Oral bioavailability is approximately 77% and plasma protein binding is approximately 98%. The active substance is degraded by the CYP-450 system in the liver and the majority is subsequently excreted in the urine.

Toxicity

Side effects

Pantoprazole is considered to be a very safe drug with few side effects. Rare side effects include dizziness, headache, and diarrhea.

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The contents shown do not replace the original package insert of the medicinal product, especially with regard to dosage and effect of the individual products. We cannot assume any liability for the correctness of the data, as the data was partly converted automatically. A doctor should always be consulted for diagnoses and other health questions. Further information on this topic can be found here.

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