Like all medicines, Temozolomide Hospira can cause side effects, although not everybody gets them.
Patients taking temozolomide in combination with radiation therapy may experience different side effects than patients taking temozolomide alone.
Contact your doctor immediately if you have a severe allergic reaction (rash which might be itchy, wheezing or other breathing difficulty), uncontrolled fits, fever or a severe headache that does not go away.
Temozolomide treatment can cause a reduction in certain kinds of blood cells. This may cause you to have increased bruising or bleeding, anaemia, fever, and/or a reduced resistance to infections. The reduction of blood cells is usually temporary, but in some cases may be for longer and may lead to a very severe form of anaemia (aplastic anaemia). Your doctor will monitor your blood regularly for any changes, and will decide if any specific treatment is needed. In some cases, your temozolomide dose will be reduced or discontinued.
The following side effects may occur if you are a newly diagnosed patient taking Temozolomide Hospira for a specific brain tumour (glioblastoma multiforme) in combination treatment with radiotherapy and then later taking temozolomide on its own. Medical attention may be required.
The frequency of possible side effects listed below is defined using the following convention: very common (affects more than 1 user in 10)
common (affects 1 to 10 users in 100)
uncommon (affects 1 to 10 users in 1,000)
rare (affects 1 to 10 users in 10,000)
very rare (affects less than 1 user in 10,000)
not known (frequency cannot be estimated from the available data).
Very common side effects:
Headache constipation feeling andor being sick rash hair loss loss of appetite tiredness
Common side effects:
Abnormal liver function tests, changes in blood cells, fits, change in mental status or alertness, sleepiness, difficulty with your balance, dizziness, confusion, forgetfulness, difficulty concentrating, tingling sensation, pins and needles, difficulty speaking or understanding language, shaking, stroke. abnormal or blurred vision, double-vision loss of hearing, ringing noise in the ear shortness of breath, cough sores or ulcers in the mouth, diarrhoea, stomach pain, heartburn, difficulty swallowing, dry mouth frequent urination, difficulty with holding your urine or urine leakage skin irritation or redness, dry skin, itching muscle weakness, painful joints, muscle aches and pains increased sugar in the blood, loss of weight infections, wound infection, sore throat, fungal infections in the mouth, cold sores bleeding, fluid retention, swollen legs, blood clots allergic reaction, fever, radiation injury, facial swelling, pain, changes in sense of taste anxiety, depression, changing emotions, inability to fall asleep or stay asleep,
raised liver enzymes your doctor will check this palpitations abnormal heart beats flu-like symptoms, red spots under the skin long or repeated fits, tremors or jerking movement, partial paralysis, difficulty with your coordination and balance, difficulty swallowing, changes in sensation of touch partial loss of vision, dry or painful eyes infection of the middle ear, pain or discomfort in the ears from loud noises, earache, deafness, feeling that ones surroundings are spinning pneumonia, inflammation of your sinuses, bronchitis, blocked nose, a cold or the flu
bloated stomach, difficulty controlling your bowel movements, haemorrhoids piles pain with urination peeling skin, increased skin sensitivity to sunlight, change in skin colour, increased sweating muscle damage, back pain appearance of a swollen or moon face low potassium level in the blood, weight gain shingles, flu-like symptoms bleeding within the brain, high blood pressure, blood clot in the lung, swelling weakness, swollen face, shivering, change in your sense of taste, tooth disorder sexual impotence, vaginal bleeding, absent or heavy menstrual periods, vaginal irritation, breast pain, mood swings, depression, hallucination and memory loss discolouration of your tongue change in your sense of smell thirst
The following side effects may occur if you are taking only temozolomide (patients treated for
brain tumours that have come back or that have spread)
Abnormal blood values, headache, feeling or being sick, constipation, loss of appetite, tiredness
Sleepiness, dizziness, tingling sensation, diarrhoea, stomach pain, indigestion, rash, itching, hair loss, weight loss, fever, weakness, shivering, feeling unwell, pain, change in taste, shortness of breath
Changes in blood cells
Infections including agents causing pneumonia.
Skin redness, an itchy rash with raised yellow or white lumps that are surrounded by red inflammation, skin eruption, allergic reactions.
Very rare cases of lung side effects have been observed with temozolomide. Patients usually present with shortness of breath and cough. Tell your doctor if you notice any of these symptoms.
Very rare cases of rash with skin swelling, including on the palms of the hands and soles of the feet, or painful reddening of the skin and/or blisters on the body or in the mouth have been observed. Tell your doctor immediately if this occurs.
Very rarely, patients taking temozolomide and medicines like it may have a small risk of other changes in blood cells, including leukaemia.
If any of the side effects gets serious, or if you notice any side effects not listed in this leaflet, please tell your doctor or pharmacist.