Like all medicines, Norvir can cause side effects, although not everybody gets them. Also, the side effects of Norvir when used with other antiretroviral medicines are dependent on the other medicines. So it is important that you carefully read the side effects section of the leaflets that are provided with these other medicines.
The frequency of possible side effects listed below is defined using the following convention:
very common common uncommon rare very rare not known affects more than 1 user in 10 affects 1 to 10 users in 100 affects 1 to 10 users in 1,000 affects 1 to 10 users in 10,000 affects less than 1 user in 10,000 frequency cannot be estimated from the available data.
Very common side effects:
- stomach ache ? a tingling sensation or numbness in
- vomiting the hands, feet or around the lips and ? diarrhoea mouth ? feeling sick (nausea) ? feeling weak/tired ? headache ? bad taste in the mouth
Common side effects:
- allergic reactions including skin ? sore throat rashes (may be red, raised, itchy), ? increased cough severe swelling of the skin and ? wind (flatulence) other tissues ? loss of appetite ? difficulty in breathing ? dry mouth ? flushing of the skin (vasodilation) ? belching ? changes in fat distribution (see ? mouth ulcer Side effects associated with ? sweating combination antiretroviral ? muscle aches therapy below) ? fever ? dizziness ? pain ? inability to sleep (insomnia) ? weight loss ? anxiety ? laboratory test results: ? sleepiness changes in blood test results ? numbness (such as blood chemistry and ? unusual sensitivity of the skin blood count)
Uncommon side effects:
- dehydration (thirst) ? hepatitis (inflammation of the liver)
- diabetes ? laboratory test results:
- jaundice (yellowing of the skin changes in blood test results (such or whites of eyes as blood chemistry and blood count)
- muscle pain, tenderness or weakness
Rare side effects:
- severe or life threatening skin ? serious allergic reaction (anaphylaxis) reaction including blisters ? high levels of sugar in the blood (Stevens Johnson syndrome)
Other side effects that have been reported with Norvir: low levels of blood platelets, kidney failure, seizures (fits), fainting and feeling faint when getting up, abnormally heavy periods. It is not known how frequently these effects may occur.
Tell your doctor if you fee sick (nauseous), are vomiting, or have stomach pain, because these may be signs of an inflamed pancreas. Also tell your doctor if you experience joint stiffness, aches and pains (especially of the hip, knee and shoulder) and difficulty moving, as this may be a sign of osteonecrosis. See also section 2 Before you take Norvir.
Side effects associated with combination antiretroviral therapy may cause changes in body shape due to changes in fat distribution. These may include loss of fat from legs, arms and face, increased fat in the abdomen (belly) and internal organs, breast enlargement and fatty lumps on the back of the neck ("buffalo hump"). The cause and long-term health effects of these conditions are not known. Combination antiretroviral therapy may also cause raised lactic acid and sugar in the blood, increased fats in the blood and resistance to insulin (insulin will not work as effectively).
In patients with haemophilia type A and B, there have been reports of increased bleeding while taking this treatment or another protease inhibitor. Should this happen to you, seek immediate advice from your doctor.
Cases of diabetes mellitus or increased blood sugars have been reported in patients receiving Norvir or other protease inhibitors.
Abnormal liver function tests, hepatitis (inflammation of the liver), and rarely jaundice, have been reported in patients taking Norvir. Some people had other illnesses or were taking other medicines. People with liver disease or hepatitis may have worsening of liver disease.
There have been reports of muscle pain, tenderness or weakness, particularly when taking medicines to lower cholesterol in combination with antiretroviral therapy, including protease inhibitors and nucleoside analogues. On rare occasions these muscle disorders have been serious (rhabdomyolysis). In the event of unexplained or continual muscle pain, tenderness, weakness or cramps, stop taking the medicine, contact your doctor as soon as possible or go to the Accident and Emergency Department of your nearest hospital.
Inform your doctor as soon as possible if you experience any symptoms that suggest an allergic reaction after taking Norvir such as rash, hives or breathing difficulties.
If any of the side effects gets serious, or if you notice any side effects not listed in this leaflet, contact your doctor, pharmacist, Accident and Emergency department or if it is urgent get immediate medical help.